Endocrine Abstracts

Objectives: Phosphatase and tension homolog (PTEN) is a part of signal pathways which are essential for cell proliferation, cell cycle progression, and apoptosis. Variants in the PTEN gene occur in different types of thyroid tumors with unclear diagnostic and prognostic impact. Most variants are somatic, but they can also be germline, which are associated with PTEN hamartoma tumor syndrome (PHTS). PHTS includes Cowden syndrome, which is characterized by hamartomas, an...

We present a case report of a 56-year-old woman with MEN1 syndrome diagnosed at the age of 28 years. It was completely expressed by the set – insulinoma, prolactinoma and primary hyperparathyroidism. She underwent resection of 2/3 of the pancreas for symptomatic hypoglycaemia in the age of 28 years (1991). After two resections of parathyroid glands hypocalcaemia replacement was necessary. Prolactinoma was transiently treated with dopamine agonists. In the age of 45 years ...

Objectives: ALK fusion genes are a rare genetic alteration and have been described in various t types of thyroid carcinomas, particularly in papillary thyroid carcinomas (PTCs), poorly differentiated thyroid carcinomas (PDTCs) and anaplastic thyroid carcinomas (ATCs). The aim of this study was to identify ALK fusion genes in thyroid carcinoma samples, correlate them with clinical and histopathological features, and determine the prognostic significance of <em...